Diphenylmethane bromide → [(2-Diphenylmethylthio-4,5-dihydronaphtho[1,2-d]thiazol-7-yl)oxy]acetic acid

HRID 2228685Notes

Reaction equation

[SH:1][C:2]1[S:3][C:4]2[CH2:14][CH2:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH2:16][C:17]([O:19]CC)=[O:18])[CH:11]=3)[C:5]=2[N:6]=1.[Br-].[C:23]1([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([CH:29]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[S:1][C:2]2[S:3][C:4]3[CH2:14][CH2:13][C:12]4[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH2:16][C:17]([OH:19])=[O:18])[CH:11]=4)[C:5]=3[N:6]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

Reactant 2

HCID 18470978Diphenylmethane bromide

HCID 178472938HCID 178472938, compound

Product 1

HCID 18471103[(2-Diphenylmethylthio-4,5-dihydronaphtho[1,2-d]thiazol-7-yl)oxy]acetic acidYield 50%

Procedure

Using ethyl [(2-mercapto-4,5-dihydronaphto[1,2-d]thiazol-7-yl)oxy]acetate and diphenylmethane bromide, the procedure of Example 1 was otherwise repeated to synthesize the title compound. Yield 50%.

Sources & evidence

ORD record: ord-4fd7c90fda2f4df8a61bf211e653bd9d
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06417213B2

Reaction notes

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