Acetamide, 2,2-diphenylthio- → [(2-Diphenylmethyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic acid

HRID 2228705Notes

Reaction equation

HRID 2228705 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9]2[C:8](=O)[CH2:7][CH2:6][CH2:5][C:4]=2[C:3]=1[O:13][CH2:14][C:15]([O:17]CC)=[O:16].[C:20]1([CH:26]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:27]([NH2:29])=[S:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:20]1([CH:26]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:27]2[S:28][C:7]3[CH2:6][CH2:5][C:4]4[C:9](=[CH:10][CH:11]=[CH:2][C:3]=4[O:13][CH2:14][C:15]([OH:17])=[O:16])[C:8]=3[N:29]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 2734828Acetamide, 2,2-diphenylthio-HCID 21193671Ethyl [(2-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate

Product 1

HCID 18471097[(2-Diphenylmethyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic acidYield 31%

Procedure

Using ethyl [(2-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate and diphenylthioacetamide, the procedure of Example 52 was otherwise repeated to synthesize the title compound. Yield 31%.

Sources & evidence

ORD record
ord-661f64178b4f43ddb6bbba9bce918c51
Source dataset
uspto-grants-2002_07
Patent number
US06417213B2

Reaction notes

Loading…