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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2228707Generated: October 30, 2026

Ethyl[(6-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate → [(2-(2,2-Diphenylethyl)-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic acid

https://huagongshe.com/reaction/2228707

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl[(6-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetateHCID 21193655—
ReactantBenzhydrylthioacetamideHCID 22066262—
Product[(2-(2,2-Diphenylethyl)-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic acidHCID 1847107819%

Reaction Steps

Using ethyl [(6-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate and 3,3-diphenylthiopropionamide, the procedure of Example 52 was otherwise repeated to synthesize the title compound. Yield 19%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06417213B2
Source datasetuspto-grants-2002_07
ORD IDord-834585248ad34b009c5b8930720465d7
Source noteuspto-grants-2002_07