HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-(Bromomethylene)bis(4-fluorobenzene) → [(2-Bis(4-fluorophenyl)methylthio-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-(Bromomethylene)bis(4-fluorobenzene) | HCID 67665 | — |
| Reactant | Ethyl[(2-mercapto-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy)acetate | HCID 178472952 | — |
| Product | [(2-Bis(4-fluorophenyl)methylthio-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic acid | HCID 18471045 | 77% |
Reaction Steps
Using ethyl [(2-mercapto-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetate and bis(4-fluorophenyl)methyl bromide, the procedure of Example 63 was otherwise repeated to synthesize the title compound. Yield 77%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06417213B2 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-4caf2665765146fd8af9c369b15a0920 |
| Source note | uspto-grants-2002_07 |