Sodium Methoxide → HCID 86758336, compound

Participants

Reaction Conditions

Reaction Steps

34.7 g of solid sodium methoxide in 250 ml of DMF were stirred at 23° C. for 3 hours and 120 g of the amide from Example 6 in 250 ml of DMF were then added dropwise (temperature increase to up to 30° C.). The mixture was subsequently stirred at 23° C. for 12 hours and then worked-up as in Example 6. This gave 108 g of the title compound as a colorless solid which, according to NMR, GC and HPLC analysis, contains approximately 10% of the starting material (Example 6).

Provenance & Evidence