Sodium Methoxide → HCID 86758339, compound

Participants

Reaction Conditions

Reaction Steps

48.4 g of solid sodium methoxide in 400 ml of DMF were stirred at 23° C. for 3 hours, and 174 g of the amide from Example 8 in 250 ml of DMF were then added dropwise. The mixture was subsequently stirred at 23° C. for 18 hours and then worked-up similarly to Example 6. This gave 154 g of the title compound as a colorless solid which, according to NMR, GC and HPLC analysis, contained approximately 12% of the starting material (Example 8).

Provenance & Evidence