HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2228858Generated: November 3, 2026
Ethanol → 2-chloro-6-fluoro-N'-hydroxybenzenecarboximidamide
https://huagongshe.com/reaction/2228858
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Chloro-6-fluorobenzonitrile | HCID 69587 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-chloro-6-fluoro-N'-hydroxybenzenecarboximidamide | HCID 4623427 | — |
Reaction Steps
A mixture of 15.6 g of 2-chloro-6-fluorobenzonitrile, 9.0 g of hydroxylamine hydrochloride, 7.4 g of sodium carbonate, 50 ml of ethanol and 15 ml of water was stirred at 70-75° C. for 16 h. The solvent was evaporated and the residue was stirred with tertbutyl methyl ether, and the filtrate afforded, after evaporation of the solvent, 17.6 g of the desired product of m.p. 115-120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06417398B1 |
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| Source dataset | uspto-grants-2002_07 |
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| ORD ID | ord-5be28282c74240769217d730973e239e |
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| Source note | uspto-grants-2002_07 |
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