Hydrogen Bromide → HCID 13615094, compound

Participants

Reaction Steps

To a cooled (0° C.) solution of L-Isoleucine (66 g) dissolved in HBr (6N, 500 ml) was added dropwise a solution of sodium nitrite (35 g in 100 ml water). The reaction was stirred overnight at room temperature and then extracted with EtOAc (3×150 ml). The combined organic extracts washed with 10% sodium bisulfit solution, water, saturated brine, dried over MgSO4, filtered and concentrated. The product a yellowish oil (53.9 g) was obtained in 55% yield. (The product can be purified by distillation and crystallization from PE). (see FIG. 6)

Provenance & Evidence