HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2228876Generated: October 30, 2026
Methyl but-2-ynoate → Methyl 2-methyl-4-trimethylsilyloxybenzoate
https://huagongshe.com/reaction/2228876
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl but-2-ynoate | HCID 141019 | — |
| Reactant | 2-(Trimethylsiloxy)-1,3-cyclohexadiene | HCID 4095656 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 2-methyl-4-trimethylsilyloxybenzoate | HCID 21879730 | 67.1% |
Reaction Steps
A 50 mL round bottom flask equipped with magnetic stir bar and condenser was charged with 6.0 g of 2-trimethylsilyloxy-1,3-cyclohexadiene, 3.5 g methyl tetrolate in 3 mL dry toluene. The reaction was heated to 150° C. for 50 hours at which point 1H-NMR indicated no starting diene. The raction was concentrated in vacuo to provide 5.7 g (67%) methyl 2-methyl-4-trimethylsilyloxybenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06417387B1 |
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| Source dataset | uspto-grants-2002_07 |
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| ORD ID | ord-d4c6df2295084268930192d489305aa7 |
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| Source note | uspto-grants-2002_07 |
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