Acetone → 6-Methyl-2-heptanone
Reaction equation
[CH:1](=O)[CH2:2][CH:3]([CH3:5])[CH3:4].[CH3:7][C:8]([CH3:10])=[O:9]>>[CH3:4][CH:3]([CH3:5])[CH2:2][CH2:1][CH2:7][C:8](=[O:9])[CH3:10]Participants
3
Reactant 2
Product 1
Procedure
This latter embodiment is described below in an example of reacting acetone with isovaleraldehyde to produce 6-methylheptan-2-one. The reaction proceeds in situ via the aldolization stage yielding the corresponding β-hydroxyketone, which is not isolated. Under the reaction conditions elimination of water takes place with the formation of 6-methylhept-3-en-2-one, which is selectively hydrogenated by the homogeneously distributed hydrogenation catalyst in the lipophobic alcohol phase to form the corresponding methyl ketone.
Sources & evidence
- ORD record
- ord-02b833170e1b42db9865b4bd8b6bfd2e
- Source dataset
- uspto-grants-2002_07
- Patent number
- US06417406B1
Reaction notes
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