p-Chlorothiophenol → HCID 18470318, compound

Participants

Reaction Conditions

Reaction Steps

To 1,7-dibromoheptane (23 g) and potassium carbonate (10 g) in dry dimethylformamide (100 ml) was added 4-chlorothiophenol (4.3 g) dropwise with stirring at 25° C. After 6 h, the mixture was filtered and the solvent removed under reduced pressure. Chromatography of the residue on silica gel using hexane as eluent gave 1-bromo-7-(4-chlorophenylthio)heptane (9.6 g). 1H-NMR (CDCl3) δ 1.2-1.55 (6H, m), 1.55-1.75 (2H, m), 1.8-2.0 (2H, m), 2.89 (2H, t), 3.40 (2H, t) and 7.2-7.4 (4H, m).

Provenance & Evidence