Water → HCID 18470387, compound

Participants

Reaction Steps

To a solution of 6-amino-1-hexanol (12.9 g) and diisopropylethylamine (11.9 g) in dry dichloromethane (100 ml) at 5° C. was added 4-chlorobenzoyl chloride (16.1 g) in dry dichloromethane at such a rate to maintain the temperature below 10° C. After stirring for 16 h, the mixture was poured into water and filtered. The solid was washed with water, 2M hydrochloric acid (150 ml), water, dichloromethane and was dried under reduced pressure to give 6-(4-chlorobenzoylamino)hexan-1-ol (19.2 g). 1H-NMR (d6-DMSO) δ 1.25-1.65 (8H, m), 3.24 (2H, q), 3.38 (2H, t), 7.52 (2H, m), 7.84 (2H, m) and 8.54 (1H, bt)

Provenance & Evidence