HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-((5-Pyrimidyl)methyl)-3-methoxyacrylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-((5-pyrimidyl)methyl)-3-methoxyacrylate | HCID 53865474 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-((5-Pyrimidyl)methyl)-3-methoxyacrylic acid | HCID 54387032 | 64.3% |
Reaction Steps
To methyl 2-((5-pyrimidyl)methyl)-3-methoxyacrylate (9.0 g) was added, with stirring, a solution of sodium hydroxide (3.5 g) in water (43 ml) at RT under argon. After 20 h, the pH of the solution was brought to 3.5 with concentrated hydrochloric acid. Sonication of the oil so formed gave 2-((5-pyrimidyl)methyl)-3-methoxyacrylic acid (5.4 g) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06417192B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-28f73215525b40ba83eadeebd653a4dd |
| Source note | uspto-grants-2002_07 |