Benzenesulfonyl chloride → HCID 18470485, compound

Participants

Reaction Steps

Benzenesulfonyl chloride (41 mg) was added to a solution of 2-(8-(4chlorophenyl)oct-1-yl)thio-5-(pyrid-3-ylmethyl)pyrimidin-4-one (103 mg) in pyridine (0.5 ml), and the mixture stirred overnight. Evaporation of the pyridine followed by chromatography (silica, 0-2% methanol in dichloromethane) gave 1-phenylsulfonyl-2-(8-(4-chlorophenyl)oct-1-yl)thio-5-(pyrid-3-ylmethyl)pyrimidin-4-one (25 mg). 1H-NMR (CDCl3) δ 1.2-1.5(8H, m), 1.5-1.8(4H, m), 2.56(2H, t), 2.92(2H, t), 3.87(2H, s), 7.08(2H, d), 7.15-7.8(7H, m), 7.95(2H, m), 8.29(1H, s) and 8.35-8.7(2H, bm).

Provenance & Evidence