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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2228945Generated: November 1, 2026

Nicotinic Acid → 2-cyclohexyl-2,3-dihydro-6-[4-(pyridine-3-carbonyl)piperazin-1-yl]-1H-isoindol-1-one

https://huagongshe.com/reaction/2228945

Reaction equation

Participants

RoleNameHCIDCharge
ReactantNicotinic AcidHCID 938—
ReactantHCID 22180413HCID 22180413—
Product2-cyclohexyl-2,3-dihydro-6-[4-(pyridine-3-carbonyl)piperazin-1-yl]-1H-isoindol-1-oneHCID 12043723—

Reaction Steps

In the same manner as in Example 35, the title compound was prepared from the compound obtained in step (e) of Example 1 and nicotinic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06417362B1
Source datasetuspto-grants-2002_07
ORD IDord-2cbe44e0394048ae893d878a6060886a
Source noteuspto-grants-2002_07