Hydrochloric Acid → HCID 18510807, compound

Participants

Reaction Steps

The compound (22 mg) obtained in step (b) just above was stirred in a mixed solution of ethanol:concentrated hydrochloric acid=10:1 at room temperature for 30 min. Water was added to the reaction solution. The mixture was extracted with ethyl acetate, and then dried over anhydrous magnesium sulfate. The solvent was then removed by distillation. The residue was purified by chromatography on silica gel (hexane ethyl acetate=1:1) to give 2-cyclohexyl-2H-isoquinolin-1-one (18 mg).

Provenance & Evidence