Sodium ethoxide → HCID 69313539, compound

Participants

Reaction Steps

Freshly prepared sodium ethoxide (from 50 mg (2.2 mmol) Na) was charged with 2-(4-Dimethylcarbamoylsulfanyl-phenoxy)-2-methyl-propionic acid ethyl ester (420 mg, 1.35 mmol) and refluxed for 3 h. Toluene-4-sulfonic acid 2-(5-methyl-2-biphenyl-4-yl-oxazol-4-yl)-ethyl ester (2.2 mmol) was added and the mixture was refluxed for another 3 h. The reaction was cooled and concentrated. The residue was shaken with ethyl acetate/water. After a second water wash, the organic layer was dried (MgSO4) and concentrated to give 500 mg crude product.

Provenance & Evidence