HRID2229092

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID702

Ethanol

C2H6O

HCID1030

1,2-Propylene glycol

C3H8O2

结构：CC(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1

HCID47576

(-)-Ketoconazole

C26H28Cl2N4O4

HCID178507853

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1.Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]

HCID178473888

未命名化合物

收率 2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

0.4 g of the minoxidil of Example 1 and 0.4 g ketoconazole available from Janssen Pharmaceutica N.V., Beerse, Belgium, were added with stirring at ambient temperature and pressure into a beaker containing 4 ml of propylene glycol, 12 ml of ethanol, and 4 ml water to produce a 2% minoxidil/ketoconazole-containing solution.

WORKUP

后处理

addition, Beerse, Belgium, were added

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-69d6cbcf4e904a1395f3fd84dc52c0df
来源数据集: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06419913B1
来源说明: uspto-grants-2002_07

反应 SMILES

[CH:1]1[C:2]([NH2:15])=[N+:3]([O-:14])[C:4]([NH2:13])=[N:5][C:6]=1[N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.[CH3:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:26]=[CH:27][C:28]([O:31][CH2:32][C@H:33]3[O:37][C@@:36]([C:44]4[CH:45]=[CH:46][C:47]([Cl:51])=[CH:48][C:49]=4[Cl:50])([CH2:38][N:39]4[CH:43]=[N:42][CH:41]=[CH:40]4)[O:35][CH2:34]3)=[CH:29][CH:30]=2)[CH2:21][CH2:20]1)=[O:18].C(O)C(O)C.C(O)C>O>[CH:1]1[C:2]([NH2:15])=[N+:3]([O-:14])[C:4]([NH2:13])=[N:5][C:6]=1[N:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.[CH3:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:26]=[CH:27][C:28]([O:31][CH2:32][C@H:33]3[O:37][C@@:36]([C:44]4[CH:45]=[CH:46][C:47]([Cl:51])=[CH:48][C:49]=4[Cl:50])([CH2:38][N:39]4[CH:43]=[N:42][CH:41]=[CH:40]4)[O:35][CH2:34]3)=[CH:29][CH:30]=2)[CH2:21][CH2:20]1)=[O:18]