HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → HCID 18466516, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | 5-Chloro-2,3-difluoropyridine | HCID 2783248 | — |
| Catalyst | Copper | HCID 23978 | — |
| Product | HCID 18466516 | HCID 18466516 | — |
Reaction Steps
Starting from 93 g (0.508 mol) of 2,3-difluoro-5-chloropyridine, 58.8 g (0.5276 mol) of 98.7% pure thiophenol and 3.2 mg (0.01 mol %) of copper powder, 121.5 g (99.9% of theory) of the title compound were obtained as a colorless oil after 1.5 h of stirring in a pressure apparatus at 185° C. and work-up by the method of Example 1. 1H NMR (ppm, d6-DMSO) 8.35 (s/1H), 8.05 (d/1H), 7.4-7.6 (m/5H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420314B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-bbc25ae9f2c444db92e2b6e8f6f28603 |
| Source note | uspto-grants-2002_07 |