Hydrogen Bromide → HCID 18466525, compound

Participants

Reaction Steps

8.5 g (0.0263 mol) of 3-fluoro-2-(4-chloro-2-fluoro-5-methoxyphenyl)-5-trifluoromethylpyridine were added with stirring to 110 ml of 47% strength hydrobromic acid, and the mixture was refluxed for 2 h. After cooling, the clear solution was poured into 500 ml of water and extracted with methylene chloride. The organic phase was extracted with 1 N sodium hydroxide solution and the extract was acidified and extracted with ethyl acetate. Drying and concentration yielded 6.7 g (82.1% of theory) of the title compound of mp. 94-96° C.

Provenance & Evidence