Water → HCID 18466520, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.25 g (0.808 mmol) of the compound of Example 7, 0.12 g (0.97 mmol) of propargyl bromide and 0.22 g (1.62 mmol) of potassium carbonate powder in 10 ml of DMF was stirred for 2 h at 65-70° C. After cooling, 50 ml of water were added and the mixture was extracted 3 times with methyl tert-butyl ether, and the extracts were dried and concentrated, affording 0.28 g (100% of theory) of the title compound of mp. 68-70° C.

Provenance & Evidence