Methylhydrazine → HCID 23150870, compound

HRID 2229163Notes

Reaction equation

HRID 2229163 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([CH2:8][C:9](OCC)=[O:10])=O)=[CH:4][CH:3]=1.[CH3:16][NH:17][NH2:18]>C(O)C>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]2[NH:18][N:17]([CH3:16])[C:9](=[O:10])[CH:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 101336Ethyl 3-(4-chlorophenyl)-3-oxopropanoate

Product 1

HCID 23150870HCID 23150870, compoundYield 43.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 4-chlorobenzoylacetate (500 mg) in 4 ml of ethanol was added 202 mg of methylhydrazine and the resulting mixture was stirred over night at room temperature. The solvent was removed under reduced pressure and to the residue was purified by the use of silica gel column chromatography to give 199 mg of 3-(4-chlorophenyl)-1-methylpyrazoline-5-one.

Workup

  1. customThe solvent was removed under reduced pressure and to the residue
  2. customwas purified by the use of silica gel column chromatography

Sources & evidence

ORD record
ord-e0d220a10459485e9aeba943c1c696d7
Source dataset
uspto-grants-2002_07
Patent number
US06420367B1

Reaction notes

Loading…