Potassium Carbonate → HCID 18466902, compound

Participants

Reaction Steps

A solution of 11.94 g of the 3:2 mixture of ethyl 3-bromo-4-(2-methoxy-5-bromophenyl)-2-oxobutanoate and ethyl 3-(2-methoxy-5-bromophenyl)propanoate in 150 mL of ethanol is treated with 2.85 g (30.0 mmol) of 2-aminopyrazine and heated to reflux temperature for 16 hr. The reaction mixture is cooled to room temperature and treated with 10 g of potassium carbonate. The mixture is filtered through Celite and the solvent removed in vacuo to yield the crude material. The resulting residue is flash chromatographed with initially 1% methanol in dichloromethane and then 3% methanol in dichloromethane to afford 3.7 g (48% based on starting material) ethyl 3-[(5-bromo-2-methoxyphenyl)methyl]-imidazolo[1,2-a]pyridine-2-carboxylate.

Provenance & Evidence