Boron tribromide → HCID 22091465, compound

Participants

Reaction Steps

A solution of 416 mg (1.0 mmol) of ({3-[(5-bromo-2-methoxyphenyl)methyl](imidazolo[1,2-a]pyridin-2-yl)}methyl) (3-methylbutyl)amine in 20 mL dichloromethane at −78° C. is treated with boron tribromide 0.4 mL (4.0 mmol). The resulting solution is allowed to return to room temperature over 1 hr, quenched by addition of 10 mL sat. NaHCO3 and extracted with 2×10 mL dichloromethane. The combined extract is dried over anhydrous MgSO4 and the solvent removed in vacuo to yield 360 mg (89%) ({3-[(5-bromo-2-hydroxyphenyl)methyl](imidazolo[1,2-a]pyridin-2-yl)}methyl)(3-methylbutyl)amine.

Provenance & Evidence