Hydrochloric Acid → HCID 22091452, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of bromoethyl 2-chloro-3-bromoethoxy-4-methoxybenzoate (2.0 g, 4.8 mmol) in ethanol (6 ml) is added 2.5 N aqueous sodium hydroxide (4.8 ml, 12 mmol). The resulting mixture is heated at 50° C. until dissolved plus an additional 10 minutes. The solution is cooled, acidified with 3 N HCl, transferred to a separatory funnel and extracted with ethyl acetate (4×25 ml). The combined organic layers are washed with brine (25 ml), dried over magnesium sulfate and evaporated to obtain 1.4 g (93%) of 3-bromoethoxy-2-chloro-4-methoxybenzoic acid.

Provenance & Evidence