Thionyl Chloride → HCID 22091453, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 3-bromoethoxy-2-chloro-4-methoxybenzoic acid (1.4 g, 4.5 mmol) in thionyl chloride (20 ml) is heated at 60 ° C. until dissolved (˜20 min) plus an additional 30 minutes. The reaction mixture is cooled to room temperature and excess thionyl chloride is evaporated under reduced pressure. The resulting residue is evaporated at reduced pressure with toluene (50 ml) two times to obtain 1.5 g (100%) of 2-chloro-3-bromoethoxy-4-methoxybenzoic acid chloride.

Provenance & Evidence