Cyclopentylamine → HCID 10189495, compound

Participants

Reaction Conditions

Reaction Steps

To 0.1 ml of a 0.2 M solution of (2-chloro-3-bromoethoxy-4-methoxyphenyl)-N-({3-[(2-methoxyphenyl)methyl](imidazolo[1,2-a]pyridin-2-yl)}methyl)-N-(3-methylbutyl)carboxamide in N-methylpyrrolidinone is added 0.1 ml of a 1 M solution of cyclopentylamine. The mixture is heated at 90 ° C. for 15 h in a sealed vial. After cooling to room temperature, the reaction mixture is diluted with 0.5 ml of ethyl acetate and washed with 0.5 ml of 1 N aqueous sodium hydroxide. The organic layer is separated and purified by preparative TLC eluting with 9/1/0.5 ethyl acetate/methanol/triethylamine to obtain 11 mg of the title compound. Mass Spec m/z (M++1) 633.

Provenance & Evidence