Bromotrimethylsilane → HCID 11088649, compound

HRID 2229222Notes

Reaction equation

HRID 2229222 reaction equation
Br[Si](C)(C)C.C([O:8][P:9]([C:14]1[C:15](=[O:30])[NH:16][C:17]2[C:22]([CH:23]=1)=[CH:21][C:20]([N:24]1[CH:28]=[CH:27][CH:26]=[CH:25]1)=[C:19]([Cl:29])[CH:18]=2)(=[O:13])[O:10]CC)C>C(Cl)Cl>[Cl:29][C:19]1[CH:18]=[C:17]2[C:22]([CH:23]=[C:14]([P:9](=[O:8])([OH:10])[OH:13])[C:15](=[O:30])[NH:16]2)=[CH:21][C:20]=1[N:24]1[CH:25]=[CH:26][CH:27]=[CH:28]1

Participants

4

Reactant 2

HCID 76113BromotrimethylsilaneHCID 86758351HCID 86758351, compound

Product 1

HCID 11088649HCID 11088649, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.37 ml (25.5 mmol) of bromotrimethylsilane are added to a solution of the compound obtained in Example 27 (1.62 g, 4.25 mmol) in 30 ml of CH2Cl2, and the solution is stirred for 4 hours 30 minutes at room temperature. Evaporation to dryness is carried out, and the residue is taken up in methanol. After complete dissolution, a precipitate is observed to form, and stirring is carried out for 10 minutes at room temperature. Filtration and then rinsing with a small amount of methanol and then ether are carried out to obtain the title product.

Workup

  1. customEvaporation to dryness
  2. dissolutionAfter complete dissolution
  3. customto form
  4. stirringstirring
  5. waitis carried out for 10 minutes at room temperature
  6. filtrationFiltration
  7. washrinsing with a small amount of methanol

Sources & evidence

ORD record
ord-a65d735e01704be0a88de8131781409d
Source dataset
uspto-grants-2002_07
Patent number
US06420386B1

Reaction notes

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