Sodium Methoxide → HCID 18466981, compound

Participants

Reaction Steps

A mixture of (E)-3-(2-chloro-3-quinolinyl)-2-propen-1-ol (5.74 g) and sodium methoxide (28% in methanol; 10 ml) in MeOH (30 ml) was refluxed for 2 hours. The mixture was diluted with ethyl acetate, washed with water and brine, dried and concentrated. The residue was washed with cyclohexane-i-Pr2O to give the titled compound (4.50 g; 80%) as a colorless solid.

Provenance & Evidence