関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | Diisobutylaluminumhydride | HCID 21225700 | — |
| 反応物 | ethyl (E)-3-(6-methyl-2-naphthyl)crotonate | HCID 86758349 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (E)-3-(6-methyl-2-naphthyl)-2-buten-1-ol | HCID 18467042 | 84.1% |
反応手順
A solution of diisobutylaluminum hydride in toluene (1.5M, 30 ml) was added dropwise to a solution of ethyl (E)-3-(6-methyl-2-naphthyl)crotonate (3.62 g) in THF (50 ml) at −78° C. and the mixture was stirred at −78° C. for 15 minutes. Saturated aqueous solution of NH4Cl was added to the mixture and organic layer was washed with 1N HCl and brine, dried and concentrated. The residue was crystallized from hexane-cyclohexane gave the titled compound (2.54 g) as a colorless solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06420375B1 |
|---|
| 出典データセット | uspto-grants-2002_07 |
|---|
| ORD ID | ord-9588ffe7f37e4c1986c2b8f8b9438f10 |
|---|
| 出典メモ | uspto-grants-2002_07 |
|---|
