Imidazole → HCID 12973086, compound

Participants

Reaction Steps

To a cooled (0° C.) solution of 3-(2-naphthyl)-2-propyn-1-ol (2.67 g) in THF (100 ml) were added triethylamine (4.1 ml) and methanesulfonyl chloride (1.7 ml) successively. The mixture was stirred at room temperature for 1 hours. Imidazole (3.02 g) and NaI (0.5 g) were added to the mixture and resulting mixture was stirred at 60° C. for 3 hours. To the mixture was added water, and the mixture was concentrated. The residue was extracted with ethyl acetate. The extract was washed with water and brine, dried and concentrated. The residue was chromatographed on silica gel, eluting with ethyl acetate, followed by crystallization from cyclohexane to give the titled compound (1.05 g) as a colorless solid.

Provenance & Evidence