1-Benzofuran-2-Ylmethanol → 2-Benzofurancarboxaldehyde

HRID 2229257Notes

Reaction equation

HRID 2229257 reaction equation
[OH:1][CH2:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=1>C(Cl)Cl.O=[Mn]=O>[CH:2]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=1)=[O:1]

Participants

4

Reactant 1

HCID 27762631-Benzofuran-2-Ylmethanol

Product 1

HCID 613412-BenzofurancarboxaldehydeYield 73.5%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
30 °C

Procedure

A mixture of 2-hydroxymethylbenzofuran (6.91 g) and MnO2 (37.4 g) in CH2Cl2 (250 ml) was stirred at 30° C. for 3 days. Insoluble materials were filtered off and the filtrate was concentrated to give the titled compound (5.01 g) as colorless oil.

Workup

  1. filtrationInsoluble materials were filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-086941d110984fe08a42e1e75dd5d18f
Source dataset
uspto-grants-2002_07
Patent number
US06420375B1

Reaction notes

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