Chloroform → HCID 86758353, compound

Participants

Reaction Steps

A suspension of (2S)-4-({[(tert-butoxy)carbonylamino]iminomethyl}aminooxy)-N-methoxy-N-methyl-2-[(phenylmethoxy)carbonylamino] butanamide (120 mg, 0.27 mmol), as prepared in the preceding step, and 10% Pd/C (18 mg) in methanol (5.0 mL) and chloroform (158 mL, 1.32 mmol) was hydrogenated with a balloon until all starting amine was consumed (in about 6 to 7 h). The mixture was filtered through Celite. The filtrate was concentrated to give the title compound (80 mg, 95% yield) as a colorless oil. Mass spectrum (LCMS, ESI) calcd. for C12H26N5O5 320.4 (M+H); found: 320.0.

Provenance & Evidence