Sodium Iodide → HCID 12015797, compound

Participants

Reaction Steps

To a solution of 2-cyclohexylethyl bromide (1.50 g) in ethanol (16 ml) are added 4-picolylamine (1.00 g), anhydrous potassium carbonate (1.32 g) and sodium iodide (3.49 g), and the mixture is refluxed for 17 hours with stirring. Water is added to the reaction mixture, and the whole is extracted with ether. The organic layer is washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography to give the titled compound (Reference compound No. 2-1, 0.68 g).

Provenance & Evidence