2-(Ethylamino)-6fluoro-3-nitropyridine → 3-Amino-2-(ethylamino)-6-fluoropyridine

Participants

Reaction Steps

A solution of 2-(ethylamino)-6-fluoro-3-nitropyridine (43.2 g, 230 mmol) in THF (1 L) was stirred overnight at room temperature under hydrogen (1 atm.) in the presence of 20% Pd(OH)2/C (4.35 g). The catalyst was removed by filtration through diatomaceous earth. The filtrate was concentrated under reduced pressure to give the title compound (36.3 g, 95% yield) as a black solid.

Provenance & Evidence