m-Chloroperbenzoic acid → HCID 3010656, compound

Participants

Reaction Steps

Solid mCPBA (163 mg, 0.75 mmol) was added to a solution of 5,11-dihydro-11-ethyl-4-methyl-8-{2-(4-quinolinyloxy)ethyl}-6H-dipyrido[3,2-b:2′,3′-e] [1,4]diazepin-6-one (144 mg, 0.34 mmol) in CH2Cl2 (7.5 mL). The solution was stirred at room temperature for 2 h. The mixture was diluted with CH2Cl2 (125 mL), washed successively with aqueous 10% Na2S2O3 (2×25 mL), aqueous saturated NaHCO3 (2×25 mL) and brine (25 mL), then was dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (CH2Cl2:MeOH, 10:1) to give the title compound (102 mg, 68% yield) as a white solid: MS (ESI) m/z 442 (MH)+.

Provenance & Evidence