Nitrogen → HCID 18466626, compound

Participants

Reaction Conditions

Reaction Steps

Allyltributyltin (98 μL, 0.32 mmol) and Pd(Ph3P)4 (16 mg, 0.02 mmol) were added to a degassed (N2 through solution for 30 min) solution of 8-bromo-5,11-dihydro-11-ethyl-5-methyl-2-(trifluoromethyl)-6H-dipyrido[3,2-b:2′,3′-e] [1,4]diazepin-6-one (11 mg, 0.27 mmol) in DMF (1.4 mL) at room temperature. The mixture was stirred at 90° C. for 1.5 h then was cooled to room temperature and concentrated under reduced pressure. The residue was purified by flash chromatography (hexane:EtOAc, 8:2 to 7:3) to give the title compound (101 mg, 99% yield).

Provenance & Evidence