HRID2229358

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cl.N#CC1(NC(=O)C(CC2CCCCC2)NC(=O)N2CCOCC2)CCNCC1

HCID22260409

未命名化合物

结构：CC(C)(C)CC(NC(=O)N1CCOCC1)C(=O)NC1(C#N)CC(c2ccccc2)NC(c2ccccc2)C1

HCID22260506

未命名化合物

HCID86760541

未命名化合物

PRODUCTS

生成物

结构：CN(C)CC(=O)N1CCC(C#N)(NC(=O)C(CC2CCCCC2)NC(=O)N2CCOCC2)CC1

HCID22260588

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from N,N-dimethylaminoglycine and morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride using the coupling method described in Example 1-part (d). The product was purified by reverse phase preparative HPLC to give the title compound as an off-white solid; MS, m/z 477=M+1.

WORKUP

后处理

customThe product was purified by reverse phase preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-932818edf6454897b20902a8f51cf858
来源数据集: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06420364B1
来源说明: uspto-grants-2002_07

反应 SMILES

CNN(NC)CC(O)=O.Cl.[C:11]([C:13]1([NH:19][C:20]([CH:22]([NH:30][C:31]([N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)=[O:32])[CH2:23][CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:21])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)#[N:12].C(C1(NC(C(N[C:69]([N:71]2[CH2:76]C[O:74][CH2:73][CH2:72]2)=O)CC(C)(C)C)=O)CC(C2C=CC=CC=2)NC(C2C=CC=CC=2)C1)#N>>[C:11]([C:13]1([NH:19][C:20]([CH:22]([NH:30][C:31]([N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)=[O:32])[CH2:23][CH:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)=[O:21])[CH2:14][CH2:15][N:16]([C:73](=[O:74])[CH2:72][N:71]([CH3:76])[CH3:69])[CH2:17][CH2:18]1)#[N:12]