Sodium Carbonate → 3-Amino-1-benzylpyrrolidine-3-carbonitrile

HRID 2229362Notes

Reaction equation

HRID 2229362 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]([NH2:12])([C:10]#[N:11])[CH2:6][CH2:5]1)(=O)C.C(=O)([O-])[O-].[Na+].[Na+]>>[NH2:12][C:7]1([C:10]#[N:11])[CH2:8][CH2:9][N:4]([CH2:5][C:6]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1]1

Participants

3

Reactant 2

HCID 10340Sodium CarbonateHCID 22063213HCID 22063213, compound

Product 1

HCID 220633693-Amino-1-benzylpyrrolidine-3-carbonitrile

Procedure

3-Amino-3-cyano-1-benzylpyrrolidine was prepared by a method analogous to that of Example 1-part (a) with the exception that no sodium carbonate was added to the reaction mixture. The product was extracted from the crude reaction with 3×100 mL of EtOAc and was used without purification.

Workup

  1. additionwas added to the reaction mixture
  2. extractionThe product was extracted from the crude
  3. customreaction with 3×100 mL of EtOAc
  4. customwas used without purification

Sources & evidence

ORD record
ord-02a874c72f454e2ea43468af4604574c
Source dataset
uspto-grants-2002_07
Patent number
US06420364B1

Reaction notes

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