HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → Morpholine-4-carboxylic acid[1-(4-cyano-1-methanesulfonyl-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride | HCID 22260409 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Morpholine-4-carboxylic acid[1-(4-cyano-1-methanesulfonyl-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide | HCID 22260463 | — |
Reaction Steps
The title compound is prepared by treatment of morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride with methanesulfonyl chloride and a tertiary amine base such as N-methylmorpholine in a solvent such as methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420364B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-f950442078a04c04b8993f7acb37380c |
| Source note | uspto-grants-2002_07 |