1,1'-Thiocarbonyldi-2(1H)-pyridone → HCID 10868159, compound

HRID 2229414Notes

Reaction equation

HRID 2229414 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[C:10]1[O:14][CH:13]=[N:12][CH:11]=1)[NH2:6].[C:15](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:16]>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:6]=[C:15]=[S:16])[CH:7]=[CH:8][C:9]=1[C:10]1[O:14][CH:13]=[N:12][CH:11]=1

Participants

4

Reactant 2

HCID 8531621,1'-Thiocarbonyldi-2(1H)-pyridoneHCID 154627323-Methoxy-4-(oxazol-5-yl)aniline2×

Product 1

HCID 10868159HCID 10868159, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Methoxy-4-(5-oxazolyl)aniline, 1D, (3.50 g, 18.4 mmol) and 1,1′-thiocarbonyldi-2(2H)-pyridone (4.41 g, 18.4 mmol) in dichloromethane (100 mL) were stirred at rt for 3 h. The solvent was evaporated under vacuum, and the residue was subjected to a short column (30% AcOEt/hexane) to afford 34A (4.02 g, 94% yield) as white flakes.

Workup

  1. customThe solvent was evaporated under vacuum

Sources & evidence

ORD record
ord-9ebf3ec790604144ba9d7cee349d9a3d
Source dataset
uspto-grants-2002_07
Patent number
US06420403B1

Reaction notes

Loading…