3-Nitrophenyl isocyanate → HCID 15462733, compound

HRID 2229417Notes

Reaction equation

HRID 2229417 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][CH:11]=[N:10][CH:9]=2)=[C:4]([O:13][CH3:14])[CH:3]=1.[N+:15]([C:18]1[CH:19]=[C:20]([N:24]=[C:25]=[O:26])[CH:21]=[CH:22][CH:23]=1)([O-:17])=[O:16]>C(Cl)Cl>[N+:15]([C:18]1[CH:19]=[C:20]([NH:24][C:25]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:12][CH:11]=[N:10][CH:9]=3)=[C:4]([O:13][CH3:14])[CH:3]=2)=[O:26])[CH:21]=[CH:22][CH:23]=1)([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 768353-Nitrophenyl isocyanateHCID 154627323-Methoxy-4-(oxazol-5-yl)aniline

Product 1

HCID 15462733HCID 15462733, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 600 mg (3.2 mmol) of 1D in 20 ml of methylene chloride was added, as a solid, 525 mg (3.2 mmol) of m-nitrophenylisocyanate. A voluminous precipitate was obtained. Stirring was continued overnight. The precipitate was filtered and washed with methylene chloride to afford 1.1 g (3.1 mmol, 97%) of 49A as a yellow solid.

Workup

  1. customA voluminous precipitate was obtained
  2. filtrationThe precipitate was filtered
  3. washwashed with methylene chloride

Sources & evidence

ORD record
ord-0c41f7db2c8d431cbd6f29cb23f9c4ad
Source dataset
uspto-grants-2002_07
Patent number
US06420403B1

Reaction notes

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