HCID 15462733, compound → HCID 15462734, compound

Participants

Reaction Steps

A solution of 0.7 g (2 mmol) of 49A in 60 ml of dioxane and 30 ml of methanol was hydrogenated at rt and one atmosphere pressure over 0.14 g of 10% Pd/C catalyst. The catalyst was removed by filtration through Celite. The filtrate was evaporated to dryness to yield 0.3 g of 49B as a tan solid. The filter cake was suspended in dioxane—methanol and stirred at 50° C. for 1 hr. The hot solution was again filtered, and the filtrate evaporated to dryness to yield an additional 0.6 g of material. The combined batches were triturated with methylene chloride and the insolubles filtered to give 645 mg (2 mmoles, 100%) of 49B as a light tan powder.

Provenance & Evidence