Benzylamine → HCID 70179520, compound

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Reaction Steps

2-(2-oxo-3-benzylbenzimidazolyl)acetic acid (1.77 mmol, 0.5 g) (example 2) in DMA (5 ml) is charged with 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide HCl (2.66 mmol, 0.51 g). Benzylamine (2.48 mmol, 0.27 ml) is added to the suspension, and the mixture is stirred at room temperature for 17 hours. The solution is added dropwise into ice (50 g) and the colorless precipitate is filtered off and dried in vacuo. Recrystallisation from ethyl acetate yields the title product (47%) (R1=CH2—C(O)—NHR5, R5=benzyl, R2=benzyl, n=0).

Provenance & Evidence