Aluminium lithium hydride → HCID 18467691, compound

Participants

Reaction Steps

N-(4-Fluoro-2-nitrophenyl) 3,4,5-trimethoxybenzylamide (17.1 mmol, 6.0 g) in absolute ether (100 ml) is added to LiAlH4 (63.4 mmol, 2.4 g) in absolute ether (40 ml) and the mixture is stirred at room temperature for 16 hours. While cooling with an ice bath, the suspension is quenched with water (40 ml) and is extracted with ether (3×100 ml). The combined organic layers are dried with MgSO4, filtered and evaporated. Flash-chromatography (hexane:ethylacetate 1:1) and subsequent recrystallisation from ethanol yield the title product.

Provenance & Evidence