Benzylamine → HCID 70179213, compound

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Reaction Steps

3-[2-Oxo-3-(3,4,5-trimethoxybenzyl)-benzimidazolyl]propionic acid (1.77 mmol, 0.69 g) (example 14) in DMA (5 ml) is charged with 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide HCl (2.66 mmol, 0.51g). Benzylamine (2.48 mmol, 0.27 ml) is added to the suspension, and the mixture is stirred at room temperature for 17 hours. The solution is added dropwise into ice (50 g) and the colorless precipitate is filtered off and dried in vacuo. Recrystallisation from ethyl acetate yields the title product. (R1=(CH2)2—C(O)—NHR5, x=2. R5=benzyl, R2=3,4,5-trimethoxybenzyl, n=0).

Provenance & Evidence