Hydrochloric Acid → N-tert-butylmethanesulfonamide

Participants

Reaction Steps

Methanesulfonyl chloride (229 g) was added dropwise to a solution (800 ml) of t-butylamine (420 g) in chloroform under cooling in an ice bath for 90 minutes. After stirring for 3 hours at room temperature, the solution was refluxed under heating for 1 hour. The resulting reaction mixture was cooled with ice, made acidic by adding dilute hydrochloric acid, and extracted with chloroform. The organic layer was washed with water and dried over sodium sulfate. The resulting solution was distilled under reduced pressure to obtain N-t-butylmethanesulfonamide (244 g) as white solid. This product was immediately subjected to the next step.

Provenance & Evidence