Sodium Hydroxide → HCID 22508674, compound

Participants

Reaction Steps

1-(2-chloro-4-(thiophen-2-yl)benzyl)-6-(ethoxycarbonyl)-2-methylbenzimidazole (0.60 g), a 10% aqueous solution of sodium hydroxide (2 ml), and ethanol (5 ml) were mixed and refluxed for 15 minutes under heating. After allowing the solution to cool to room temperature. insoluble matter was removed by filtration with celite. The filtrate was adjusted to pH 6 with 1N hydrochloric acid (about 4 ml). The deposited crystals were collected by filtration, washed with 50% aqueous ethanol, and dried under reduced pressure to obtain the desired compound, 6-carboxy-1-(2-chloro-4-(thiophen-2-yl) benzyl)-2-methylbenzimidazole (0.208 g).

Provenance & Evidence