Dimethylformamide → HCID 22508792, compound

Participants

Reaction Steps

N,N-dimethylformamide (5 ml) was added to 60% sodium hydride (0.20 g, oily). Crystals of 1-(2-chloro-4-hydroxybenzyl)-6-(ethoxycarbonyl)-2-methylbenzimidazole (0.80 g) were added gradually thereto at room temperature. After stirring for 1 hour at room temperature, n-butyl bromide (0.28 g, 4.14 mmol) was added to the mixture. After further stirring for 15 hours at room temperature, water and subsequently ethyl acetate were added to the solution to effect extraction. The organic layer was separated, washed twice with water, and concentrated to obtain 0.62 g of oil.

Provenance & Evidence