N-Boc-N-methylethylenediamine → N-[3-(8-(2,6-difluorophenyl)-2-{[2-(methylamino)ethyl]amino}-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl)-4-methylphenyl]-2-thiophenecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	N-Boc-N-methylethylenediamine	HCID 2756424	—
Reactant	N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-2-thiophenecarboxamide	HCID 11947856	—
Product	N-[3-(8-(2,6-difluorophenyl)-2-{[2-(methylamino)ethyl]amino}-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl)-4-methylphenyl]-2-thiophenecarboxamide	HCID 11948278	—

Reaction Steps

The title compound was prepared as described in Example 2 from N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-2-thiophenecarboxamide and 1,1-dimethylethyl (2-aminoethyl)methylcarbamate: LC-MS in/z 547 (M+H)+, 1.80 min (ret time).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08207176B2
Source dataset	uspto-grants-2012_06
ORD ID	ord-bd6de48b5e254981b41dc0522b63789e
Source note	uspto-grants-2012_06